Lymphatic malformations in neonates often express as a chylothorax, and although rare, morbidity and mortality can be significant

Lymphatic malformations in neonates often express as a chylothorax, and although rare, morbidity and mortality can be significant. treatment must be based on individual patient and disease state characteristics as well as safety and efficacy profile of the medication. 2017;96(29) e7594. doi: 10.1097/MD.0000000000007594. [PMC free article] [PubMed] [Google Scholar] 35. Bialkowski A, Poets CF, Franz AR et al. Congenital chylothorax: a prospective nationwide epidemiological study in Germany. em Arch Dis Child Fetal Neonatal Ed /em . 2015;100(2):F169CF172. [PubMed] [Google Scholar] 36. Testoni D, Hornik CP, Neely ML et al. Safety of octreotide in hospitalized infants. em Early Hum Dev /em . 2015;91(7):387C392. [PMC free article] [PubMed] [Google Scholar] 37. Mohseni-Bod H, Macrae D, Slavik Z. Somatostatin analog (octreotide) in management of neonatal postoperative chylothorax: is it safe? em Pediatr Crit Care Med /em . 2004;5(4):356C357. [PubMed] [Google Scholar] 38. Rasiah SV, Oei J, Lui K. Octreotide in the treating congenital chylothorax. em J Paediatr Kid Wellness /em . 2004;40(9C10):585C588. [PubMed] [Google Scholar] 39. Sahin Y, Aydin D. Congenital chylothorax treated with octreotide. em Indian J Pediatr /em . 2005;72(10):885C888. [PubMed] [Google Scholar] 40. Laje P, Halaby L, Adzick NS et al. Necrotizing enterocolitis in neonates getting octreotide for the administration of congenital hyperinsulinism. em Pediatr Diabetes /em . 2010;11(2):142C147. [PubMed] [Google Scholar] 41. Arevalo RP, Bullabh P, Krauss AN et al. Octreotide-induced hypoxemia and pulmonary hypertension in early neonates. em J Pediatr Surg /em . 2003;38(2):251C253. [PubMed] [Google Scholar] 42. Shillitoe BMJ, Berrington J, Athiraman N. Congenital pleural effusions: 15 years single-centre encounter from North-East Britain. em J Matern Fetal Neonatal Med /em . 2018;31(15):2086C2089. [PubMed] [Google Scholar] 43. Horvers M, Mooij CF, Antonius TA. Can be octreotide treatment useful in individuals with congenital chylothorax? em Neonatology /em . 2012;101(3):225C231. [PubMed] [Google Scholar] 44. Andreou A, Papouli M, Papavasiliou V et al. Postoperative chylous ascites inside a neonate treated effectively with octreotide: bile sludge and cholestasis. em Am J Perinatol /em . 2005;22(8):401C404. [PubMed] [Google Scholar] 45. Radetti G, Gentili L, Paganini C et al. Cholelithiasis in a new baby following treatment using the somatostatin analogue octreotide. em Eur J Pediatr /em . 2000;159(7):550. [PubMed] [Google Scholar] 46. Hammill AM, Wentzel M, Gupta A et al. Sirolimus for the treating challenging vascular anomalies in kids. em Pediatr Bloodstream Tumor /em . 2011;57(6):1018C1024. [PubMed] [Google Scholar] 47. Laforgia N, COL5A2 Schettini F, De Mattia D et al. Lymphatic malformation in newborns as the 1st indication of diffuse lymphangiomatosis: effective treatment with sirolimus. em Neonatology /em . 2016;109(1):52C55. [PubMed] [Google Scholar] 48. Reinglas J, Ramphal R, Bromwich M. The effective administration of diffuse lymphangiomatosis using sirolimus: an instance record. em Laryngoscope /em . 2011;121(9):1851C1854. [PubMed] [Google Scholar] 49. Bassi A, Syed S. Multifocal infiltrative lymphangiomatosis Masitinib reversible enzyme inhibition in a kid and effective treatment with sirolimus. em Mayo Clin Proc /em . 2014;89(12) e129. doi: 10.1016/j.mayocp.2014.05.020. [PubMed] [Google Scholar] 50. Lackner H, Karastaneva A, Schwinger W et al. Sirolimus for the treating children with different challenging vascular anomalies. em Eur J Pediatr /em . 2015;174(12):1579C1584. [PubMed] [Google Scholar] 51. Akyuz C, Atas E, Varan A. Treatment of a tongue lymphangioma with sirolimus after failing of surgical propranolol and resection. em Pediatr Bloodstream Tumor /em . 2014;61(5):931C932. [PubMed] [Google Scholar] 52. Vlahovic AM, Vlahovic NS, Haxhija EQ. Sirolimus for the treating an enormous capillary-lymphatico-venous malformation: an instance record. em Pediatrics /em . 2015;136(2):e513Ce516. [PubMed] [Google Scholar] 53. Czechowicz JA, Long-Boyle JR, Rosbe KW et al. Sirolimus for administration of complicated vascular anomalies C a suggested dosing routine for very youthful babies. em Int J Pediatr Otorhinolaryngol /em . 2018;105:48C51. [PubMed] [Google Scholar] 54. Ying H, Qiao C, Yang X et al. A complete case record of 2 sirolimus-related deaths among babies Masitinib reversible enzyme inhibition with Kaposiform hemangioendotheliomas. em Pediatrics /em . 2018;141(suppl 5):S425CS429. [PubMed] [Google Scholar] 55. Swetman GL, Berk DR, Vasanawala SS et al. Sildenafil for serious lymphatic malformations. em N Engl J Med /em . 2012;366(4):384C386. [PubMed] [Google Scholar] 56. Borcyk K, Kamil A, Hagerty K et al. Effective management of incredibly high-output refractory congenital chylothorax with chemical substance pleurodesis using 4% povidone-iodine and propranolol: an instance record. em Clin Case Rep /em . 2018;6(4):702C708. [PMC free of charge content] [PubMed] [Google Scholar] 57. Danial C, Tichy AL, Tariq U et al. An open-label research to judge sildenafil for the treating lymphatic malformations. em J Am Acad Dermatol /em . 2014;70(6):1050C1057. [PMC free of charge content] [PubMed] [Google Scholar] 58. Wang S, Zhang J, Ge W et al. Effectiveness and protection of dental sildenafil in treatment of pediatric Masitinib reversible enzyme inhibition mind and throat lymphatic malformations. em Acta.